Table 3 Clinical performance of biomarkers in diagnosing bacterial infections
Biomarker | Method | Threshold (reference range) | Sensitivity (95%-CI) | Specificity (95%-CI) | Positive Predictive Value (95%-CI) | Negative Predictive Value (95%-CI) |
|---|---|---|---|---|---|---|
nCD64 (AU MFI) | Youden’s index | 5.4 | 0.54 | 0.82 | 0.69 | 0.70 |
nCD64 (AU MFI) | Maximized specificity/PPV | 9.4 | 0.27 | 1.00 | 1.00 | 0.64 |
CRP (mg/L) | Youden’s index | 68.5 (0–10) | 0.59 | 0.69 | 0.59 | 0.68 |
CRP (mg/L) | Maximized specificity/PPV | 327.0 (0–10) | 0.07 | 1.00 | 1.00 | 0.58 |
WBC (·109 cells/L) | Youden’s index | 10.4 (4–10) | 0.69 | 0.82 | 0.75 | 0.77 |
WBC (·109 cells/L) | Maximized specificity/PPV | 29.0 (4–10) | 0.01 | 1.00 | 1.00 | 0.57 |