Risk of bias | Applicability concerns | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Domain 1: Patient selection | Domain 2: Index text | Domain 3: Reference standard | Domain 4: Flow and timing | Patient selection | Index test | Reference standard | ||||||
1. Was a consecutive or random sample of patients enrolled? | 2. Was a a case-control design avoided? | 3. Did the study avoid inappropriate exclusions? | 1. Were the index test results interpreted without knowledge of the reference standard? | 2. If a threshold was used, was it pre-specified? | 1. Is the reference standard likely to correctly classify the target condition? | 2. Were the reference standard results interpreted without knowledge of the results of the index? | 1. Was there an appropriate interval between index test and reference standard? | 2. Did all patients receive the same reference standard? | 3. Were all patients included in the analysis? | ||||
Catalano [15] | No | No | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | High | Low | Yes |
Catalano [16] | No | No | Yes | Yes | Yes | Yes | Unclear | Yes | Yes | Yes | High | Low | Yes |
Catalano [17] | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Low | Low | Yes |
Lv [18] | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Low | Low | Yes |
Menichini [19] | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Low | Low | Yes |
Miele [20] | Yes | Yes | Yes | Yes | Yes | Yes | Unclear | Yes | Yes | Yes | Low | Low | Yes |
Regine [21] | Yes | Yes | Yes | Yes | Yes | Yes | Unclear | Yes | Yes | Yes | Low | Low | Yes |
Sessa [22] | Yes | Yes | Yes | Yes | Yes | Yes | Unclear | Yes | Yes | Yes | Low | Low | Yes |
Valentino [23] | No | No | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | High | Low | Yes |
Valentino [24] | No | No | Yes | Yes | Yes | Yes | Unclear | Yes | Yes | Yes | High | Low | Yes |