Table 4 Performance of H-FABP with hs-cTnT and ECG
Test |  | AMI (n = 251) | No AMI (n = 834) | Total (n = 1085) | Proportion Negative Test (%) | Sensitivity (%) | NPV (%) |
|---|---|---|---|---|---|---|---|
Optimal combinationa : ECG positive or hs-cTnT ≥7.6 ng/L or H-FABP ≥3.9 ng/mL | Positive | 246 | 487 | 733 |  | 99.2 (97.1 to 99.8) |  |
Negative | 2 | 344 | 346 | 32.1 | Â | 99.4 (97.9 to 99.8) | |
Hs-cTnT 99th percentile threshold: ECG positive or hs-cTnT ≥14 ng/L | Positive | 235 | 253 | 488 |  | 94.8 (91.2 to 96.9) |  |
Negative | 13 | 578 | 591 | 54.8 | Â | 97.8 (96.3 to 98.7) | |
Hs-cTnT or H-FABP 99th percentile threshold: ECG positive or hs-cTnT ≥14 ng/L or H-FABP ≥ 3.6 ng/mL | Positive | 241 | 469 | 710 |  | 97.2 (94.3 to 98.6) |  |
Negative | 7 | 362 | 369 | 34.2 | Â | 98.1 (96.1 to 99.1) | |
Hs-cTnT 99th percentile with H-FABP ROC derivedb: ECG positive or hs-cTnT ≥ 14 ng/L or H-FABP ≥ 3.0 ng/mL | Positive | 243 | 546 | 789 |  | 98.0 (95.4 to 99.1) |  |
Negative | 5 | 285 | 290 | 26.9 | Â | 98.3 (96.0 to 99.3) | |
Hs-cTnT threshold for >99.0 % sensitivity: ECG or hs-cTnT ≥ 6.4 ng/L | Positive | 247 | 431 | 678 |  | 99.6 (97.8 to 99.9) |  |
Negative | 1 | 400 | 401 | 37.2 | Â | 99.8 (98.6 to 100.0) |