Skip to main content

Table 3 Performance of H-FABP with hs-cTnI and ECG using sex-specific 99th percentile hs-cTnI thresholds

From: Heart Fatty Acid Binding Protein and cardiac troponin: development of an optimal rule-out strategy for acute myocardial infarction

  

AMI (n = 255)

No AMI (n = 845)

Total (n = 1100)

Proportion Negative Test

Sensitivity

NPV

Hs-cTnI 99th percentile threshold: ECG positive or hs-cTnI ≥16 ng/L (females) and ≥34 ng/L (males)

Positive

223

126

349

 

89.9 (85.5 to 93.1)

 

Negative

25

705

730

67.7

 

96.6 (95.0 to 97.7)

Hs-cTnI or H-FABP 99th percentile threshold: ECG positive or hs-cTnI ≥16 ng/L (females) or ≥34 ng/L (males) or H-FABP ≥ 3.6 ng/mL

Positive

243

442

685

 

98.0 (95.4 to 99.1)

 

Negative

5

389

394

36.5

 

98.7 (97.1 to 99.5)

Hs-cTnI 99th percentile with H-FABP ROC deriveda: ECG positive or hs-cTnI ≥16 ng/L (females) or ≥34 ng/L (males) or H-FABP ≥ 3.1 ng/mL

Positive

245

511

756

 

98.8 (96.5 to 99.6)

 

Negative

3

320

323

29.9

 

99.1 (97.3 to 99.7)

  1. aH-FABP ROC derived threshold which maximized the combination of sensitivity and specificity in patients negative for hs-cTnI and ECG