Fig. 4

A. Contour plot of the sensitivities (white lines) and heat map of the percentage of negative test for AMI for any combination of H-FABP and hs-cTnI. Because multiple combinations of the two biomarkers can produce the same sensitivity we have plotted lines of constant sensitivity (eg 99 %). The colours represent the proportion of patients who have a negative test for each possible combination of biomarkers. Red colours represent few patients with negative tests, purple colours represent many patients with negative test. To focus on the high sensitivity areas we have limited the biomarker values displayed to ≤9 ng/mL for H-FABP and <34 ng/L for hs-cTnI. A negative test is defined when H-FABP and hs-cTnI concentrations are below the levels on the y and x axis respectively