Skip to main content

Table 5 Summary of previous studies

From: Anion gap, anion gap corrected for albumin, base deficit and unmeasured anions in critically ill patients: implications on the assessment of metabolic acidosis and the diagnosis of hyperlactatemia

Anion Gap Studies

Study

N

Sensitivity

Specificity

ROC

Iberti et al[8]

56

21%

Not Reported

Not Reported

Levraut et al[10]

498

44%

91%

0.79

Moviat et al[18]

50

45%

16%

Not Reported

Dinh et al[19]

356

39%

89%

0.76

Chawla et al[15]

285

15%

94%

0.55

Anion Gap Corrected for Albumin Studies

Study

N

Sensitivity

Specificity

ROC

Moviat et al[18]

50

100%

11%

Not Reported

Dinh et al[19]

356

75%

59%

0.75

Chawla et al[15]

285

32%

80%

0.57

Base Deficit Studies

Study

N

Results

Mikulaschek et al[11]

52

No correlation between lactate and base deficit

Waters et al [11, 24]

12

Base deficit not useful, instead misleading

Chawla et al[15]

285

Base Deficit not useful, ROC AUC = 0.64

  1. ROC = Receiver operator characteristics area under the curve, AG = anion gap, ACAG = anion gap corrected for albumin, BD = Base Deficit, sensitivity and specificity for AG and ACAG are reported at threshold of 12